Stem Cells and Regenerative Medicine

Latest articles

1. 1. Neuroscience
   2. Stem Cells and Regenerative Medicine

   16p11.2 microdeletion imparts transcriptional alterations in human iPSC-derived models of early neural development

   Julien G Roth et al.
2. 1. Developmental Biology
   2. Stem Cells and Regenerative Medicine

   RUNX1 marks a luminal castration-resistant lineage established at the onset of prostate development

   Renaud Mevel et al.

   The transcription factor RUNX1 marks a distinct lineage of luminal castration-resistant prostate cells established early during development and enriched in the periurethral region of adult mouse prostate.
3. 1. Immunology and Inflammation
   2. Stem Cells and Regenerative Medicine

   Macrophages promote endothelial-to-mesenchymal transition via MT1-MMP/TGFβ1 after myocardial infarction

   Laura Alonso-Herranz et al.

   Macrophage production of MT1-MMP upon MI contributes to adverse cardiac remodeling and worsened function by promoting EndMT via TGFB, suggesting MT1-MMP inhibition as a therapeutic option for patients with MI.
4. 1. Stem Cells and Regenerative Medicine

   A fully automated high-throughput workflow for 3D-based chemical screening in human midbrain organoids

   Henrik Renner et al.

   Automated liquid handling, whole mount staining, and clearing allow unbiased 3D quantitation of cell markers in human neural organoids with diameters of up to 1 mm at the single-cell level.
5. 1. Developmental Biology
   2. Stem Cells and Regenerative Medicine

   Opposing JAK-STAT and Wnt signaling gradients define a stem cell domain by regulating differentiation at two borders

   David Melamed, Daniel Kalderon
6. 1. Developmental Biology
   2. Stem Cells and Regenerative Medicine

   Myogenin is an essential regulator of adult myofibre growth and muscle stem cell homeostasis

   Massimo Ganassi et al.

   Cellular and molecular analyses reveal how Myogenin controls muscle stem cell quiescence and growth of adult muscle fibres.
7. 1. Developmental Biology
   2. Stem Cells and Regenerative Medicine

   GATA6 mutations in hiPSCs inform mechanisms for maldevelopment of the heart, pancreas, and diaphragm

   Arun Sharma et al.

   Analyses of human stem cells with distinct GATA6 mutations revealed a spectrum of molecular responses that drive isolated congenital heart disease or the co-occurrence of pancreas and diaphragm malformations.
8. 1. Developmental Biology
   2. Stem Cells and Regenerative Medicine

   3D Visualization of Macromolecule Synthesis

   Timothy J Duerr et al.
9. 1. Medicine
   2. Stem Cells and Regenerative Medicine

   Lysosomal protein surface expression discriminates fat- from bone-forming human mesenchymal precursor cells

   Jiajia Xu et al.

   CD107a expression divides osteogenic from adipogenic perivascular precursor cells within human white adipose tissue.
10. 1. Cancer Biology
    2. Stem Cells and Regenerative Medicine

    A single-cell atlas of the mouse and human prostate reveals heterogeneity and conservation of epithelial progenitors

    Laura Crowley et al.

    Single-cell analyses identify distinct epithelial populations that are conserved between the adult mouse and human prostate, including populations with properties of multipotent progenitors in organoid formation and tissue reconstitution assays.