Computational and Systems Biology

Latest articles

1. 1. Computational and Systems Biology
   2. Evolutionary Biology

   Evolution of multicellularity by collective integration of spatial information

   Enrico Sandro Colizzi et al.

   Selection for undifferentiated multicellularity emerges in an evolutionary cell-based model because a collective of cells performs chemotaxis better than single cells in a noisy environment.
2. 1. Computational and Systems Biology
   2. Structural Biology and Molecular Biophysics

   Investigating the trade-off between folding and function in a multidomain Y-family DNA polymerase

   Xiakun Chu et al.

   The physical interaction network encoded in the multi-domain protein native structure handles the trade-off between the fast, stable folding and the efficient, reliable function.
3. 1. Computational and Systems Biology
   2. Microbiology and Infectious Disease

   Drivers and sites of diversity in the DNA adenine methylomes of 93 Mycobacterium tuberculosis complex clinical isolates

   Samuel J Modlin et al.

   Fully assembled DNA methylomes from phylogeographically diverse clinical Mycobacterium tuberculosis complex isolates reveals 'intercellular mosaic methylation' as a source of epigenetic diversity.
4. 1. Computational and Systems Biology
   2. Neuroscience

   Bayesian inference for biophysical neuron models enables stimulus optimization for retinal neuroprosthetics

   Jonathan Oesterle et al.
5. 1. Computational and Systems Biology
   2. Neuroscience

   Training deep neural density estimators to identify mechanistic models of neural dynamics

   Pedro J Gon?alves et al.

   Deep neural networks can be trained to automatically find mechanistic models which quantitatively agree with experimental data, providing new opportunities for building and visualizing interpretable models of neural dynamics.
6. 1. Computational and Systems Biology

   A large accessory protein interactome is rewired across environments

   Zhimin Liu et al.

   A massively multiplexed multi-condition screen shows that protein interactomes are larger than previously thought and contain highly dynamic regions that reorganize to drive or respond to cellular changes.
7. 1. Computational and Systems Biology
   2. Neuroscience

   On the objectivity, reliability, and validity of deep learning enabled bioimage analyses

   Dennis Segebarth et al.
8. 1. Chromosomes and Gene Expression
   2. Computational and Systems Biology

   Caenorhabditis elegans methionine/S-adenosylmethionine cycle activity is sensed and adjusted by a nuclear hormone receptor

   Gabrielle E Giese et al.

   Metabolic activity of the methionine/S-adenosylmethionine cycle is sensed and transcriptionally regulated by a nuclear hormone receptor in Caenorhabditis elegans in order to maintain metabolic homeostasis in a tightly controlled regime.
9. 1. Cancer Biology
   2. Computational and Systems Biology

   Dynamics of nevus development implicate cell cooperation in the growth arrest of transformed melanocytes

   Rolando Ruiz-Vega et al.

   Spontaneous growth arrest of transformed melanocytes (resulting in benign “moles”) does not result from cell-autonomous oncogene-induced senescence, but can be explained by collective mechanisms used in normal tissue size control.
10. 1. Computational and Systems Biology
    2. Immunology and Inflammation

    Cytotoxic T cells swarm by homotypic chemokine signalling

    Jorge Luis Galeano Ni?o et al.