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Increased mTOR activity and metabolic efficiency in mouse and human cells containing the African-centric tumor-predisposing p53 variant Pro47Ser
Keerthana Gnanapradeepan et al.
Enhanced metabolic efficiency associated with the tumor-predisposing African-centric p53 variant.
Immunology and Inflammation
The effects of age and systemic metabolism on anti-tumor T cell responses
Jefte M Drijvers et al.
A comprehensive literature review delineates the current knowledge of how systemic context, such as age and obesity, can impact CD8
T cell function, anti-tumor immunity, and immunotherapy responsiveness.
Protein phase separation and its role in tumorigenesis
Shan Jiang et al.
The current understanding of phase separation is summarized and its emerging roles in cancer are discussed in detail.
eIF4E S209 phosphorylation licenses Myc-and stress-driven oncogenesis
Hang Ruan et al.
Functional interrogation of HOXA9 regulome in MLLr leukemia via reporter-based CRISPR/Cas9 screen
Hao Zhang et al.
reporter and genetic screens facilitated the functional interrogation of the
regulome and advanced our understanding of the molecular regulation network in
Chromosomes and Gene Expression
A small protein encoded by a putative lncRNA regulates apoptosis and tumorigenicity in human colorectal cancer cells
Xiao Ling Li et al.
Genetics and Genomics
Genome-wide CRISPR screens of oral squamous cell carcinoma reveal fitness genes in the Hippo pathway
Annie Wai Yeeng Chai et al.
Genome-wide CRISPR/Cas9 screens enable the identification of actionable vulnerabilities of oral squamous cell carcinoma, and their unique dependencies on YAP1 and WWTR1 of the Hippo pathway.
Inhibiting IRE1α-endonuclease activity decreases tumor burden in a mouse model for hepatocellular carcinoma
Nata?a Pavlovi? et al.
Immunology and Inflammation
Cytotoxic T-cells mediate exercise-induced reductions in tumor growth
Helene Rundqvist et al.
Exercise can induce metabolic changes that strikingly impact cytotoxic T cell function and in turn affect cancer progression.
Replication Study: Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs
Hongyan Wang et al.
Editors' Summary: This Replication Study did not reproduce those experiments in the original paper that it attempted to reproduce.
Reproducibility in Cancer Biology
Edited by Roger J Davis et al.
Toxicity: Fishing for protective compounds
Biochemistry and Chemical Biology
Anti-Cancer Drugs: The mitochondrial paradox
Sophie L Penman et al.
McGill University, Canada
Fox Chase Cancer Center, United States
The Wistar Institute, United States
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