Cancer Biology

Latest articles

1. 1. Cancer Biology

   Increased mTOR activity and metabolic efficiency in mouse and human cells containing the African-centric tumor-predisposing p53 variant Pro47Ser

   Keerthana Gnanapradeepan et al.

   Enhanced metabolic efficiency associated with the tumor-predisposing African-centric p53 variant.
2. 1. Cancer Biology
   2. Immunology and Inflammation

   The effects of age and systemic metabolism on anti-tumor T cell responses

   Jefte M Drijvers et al.

   A comprehensive literature review delineates the current knowledge of how systemic context, such as age and obesity, can impact CD8⁺ T cell function, anti-tumor immunity, and immunotherapy responsiveness.
3. 1. Cancer Biology

   Protein phase separation and its role in tumorigenesis

   Shan Jiang et al.

   The current understanding of phase separation is summarized and its emerging roles in cancer are discussed in detail.
4. 1. Cancer Biology

   eIF4E S209 phosphorylation licenses Myc-and stress-driven oncogenesis

   Hang Ruan et al.
5. 1. Cancer Biology

   Functional interrogation of HOXA9 regulome in MLLr leukemia via reporter-based CRISPR/Cas9 screen

   Hao Zhang et al.

   The HOXA9 reporter and genetic screens facilitated the functional interrogation of the HOXA9 regulome and advanced our understanding of the molecular regulation network in HOXA9-driven leukemia.
6. 1. Cancer Biology
   2. Chromosomes and Gene Expression

   A small protein encoded by a putative lncRNA regulates apoptosis and tumorigenicity in human colorectal cancer cells

   Xiao Ling Li et al.
7. 1. Cancer Biology
   2. Genetics and Genomics

   Genome-wide CRISPR screens of oral squamous cell carcinoma reveal fitness genes in the Hippo pathway

   Annie Wai Yeeng Chai et al.

   Genome-wide CRISPR/Cas9 screens enable the identification of actionable vulnerabilities of oral squamous cell carcinoma, and their unique dependencies on YAP1 and WWTR1 of the Hippo pathway.
8. 1. Cancer Biology

   Inhibiting IRE1α-endonuclease activity decreases tumor burden in a mouse model for hepatocellular carcinoma

   Nata?a Pavlovi? et al.
9. 1. Cancer Biology
   2. Immunology and Inflammation

   Cytotoxic T-cells mediate exercise-induced reductions in tumor growth

   Helene Rundqvist et al.

   Exercise can induce metabolic changes that strikingly impact cytotoxic T cell function and in turn affect cancer progression.
10. 1. Cancer Biology

    Replication Study: Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs

    Hongyan Wang et al.

    Editors' Summary: This Replication Study did not reproduce those experiments in the original paper that it attempted to reproduce.