74 results found
    1. Biochemistry and Chemical Biology

    Bacterial OTU deubiquitinases regulate substrate ubiquitination upon Legionella infection

    Donghyuk Shin et al.
    A novel class of bacterial OTU deubiquitinases provides insights on the distinct roles of bacterial deubiquitinases in host–pathogen interactions.
    1. Microbiology and Infectious Disease

    Interplay between bacterial deubiquitinase and ubiquitin E3 ligase regulates ubiquitin dynamics on Legionella phagosomes

    Shuxin Liu et al.
    A novel bacterial deubiquitinase with multiple chain types specificity regulates the association of ubiquitinated proteins on the phagosome of Legionella pneumophila.
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    Structure of the chromatin remodelling enzyme Chd1 bound to a ubiquitinylated nucleosome

    Ramasubramanian Sundaramoorthy et al.
    The unwrapping two turns of DNA on Chd1-bound nucleosomes cause the histone H3 tail and ubiquitin to be re-positioned.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    FACT and Ubp10 collaborate to modulate H2B deubiquitination and nucleosome dynamics

    Melesse Nune et al.
    The histone chaperone FACT and the deubiquitinating enzyme Ubp10 act in concert to remove ubiquitin from histone H2B in nucleosomes, and likely coordinate nucleosome assembly during DNA replication and transcription.
    1. Developmental Biology
    2. Neuroscience

    USP5/Leon deubiquitinase confines postsynaptic growth by maintaining ubiquitin homeostasis through Ubiquilin

    Chien-Hsiang Wang et al.
    Maintenance of ubiquitin homeostasis is essential for proper control of the size of postsynaptic density and the growth of specialized membrane structure.
    1. Structural Biology and Molecular Biophysics

    Atomic structure of the 26S proteasome lid reveals the mechanism of deubiquitinase inhibition

    Corey M Dambacher et al.
    Within the isolated lid sub-complex of the proteasome, a finely tuned network of interactions maintains the deubiquitinase in an inhibited conformation; dramatic rearrangements of the lid subunits upon incorporation into the holoenzyme lead to the deubiquitinase’s activation.
    1. Cell Biology

    COPI mediates recycling of an exocytic SNARE by recognition of a ubiquitin sorting signal

    Peng Xu et al.
    COPI vesicle coat protein recognizes a ubiquitin sorting signal on an exocytic v-SNARE to mediate recycling.
    1. Cell Biology

    ESCRTs function directly on the lysosome membrane to downregulate ubiquitinated lysosomal membrane proteins

    Lu Zhu et al.
    The lysosome membrane is a new functional location for the ESCRTs in yeast.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Transcription factor MITF and remodeller BRG1 define chromatin organisation at regulatory elements in melanoma cells

    Patrick Laurette et al.
    The PBAF chromatin-remodelling complex is essential for the proliferation of melanocytes and melanoma cells and is recruited to critical regulatory elements by physical and functional interactions with MITF, a transcription factor and master regulator of melanoma.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    The deubiquitylase Ubp15 couples transcription to mRNA export

    Fanny Eyboulet et al.
    Ubp15 regulates the ubiquitylation of the export adaptor Mex67.

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