289 results found
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    A long-term epigenetic memory switch controls bacterial virulence bimodality

    Irine Ronin et al.
    Hysteretic switching between virulence states has been observed in a human pathogen.
    1. Microbiology and Infectious Disease

    Interplay between bacterial deubiquitinase and ubiquitin E3 ligase regulates ubiquitin dynamics on Legionella phagosomes

    Shuxin Liu et al.
    A novel bacterial deubiquitinase with multiple chain types specificity regulates the association of ubiquitinated proteins on the phagosome of Legionella pneumophila.
    1. Immunology and Inflammation
    2. Neuroscience

    Intestinal infection regulates behavior and learning via neuroendocrine signaling

    Jogender Singh, Alejandro Aballay
    Feedback from the intestine during infection can modulate the behavior, learning, and microbial perception of the host.
    1. Epidemiology and Global Health
    2. Plant Biology

    Evolutionary transitions between beneficial and phytopathogenic Rhodococcus challenge disease management

    Elizabeth A Savory et al.
    The horizontal acquisition of virulence plasmids is potentiated by production practices in plant nurseries and is sufficient to transition Rhodococcus from being beneficial to being pathogenic.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Acidic pH and divalent cation sensing by PhoQ are dispensable for systemic salmonellae virulence

    Kevin G Hicks et al.
    Receptor recognition of antimicrobial peptides is important for Salmonellae to survive inside macrophages and cause disease.
    1. Epidemiology and Global Health
    2. Plant Biology

    Plant Pathology: Plasmid-powered evolutionary transitions

    Ryan A Melnyk, Cara H Haney
    The acquisition of a virulence plasmid is sufficient to turn a beneficial strain of Rhodococcus bacteria into a pathogen.
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    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Reconstitution of bacterial autotransporter assembly using purified components

    Giselle Roman-Hernandez et al.
    A complex that catalyzes the membrane integration of β barrel proteins and a molecular chaperone promote the complete assembly of a bacterial virulence factor in vitro.
    1. Microbiology and Infectious Disease

    Cell cycle constraints on capsulation and bacteriophage susceptibility

    Silvia Ardissone et al.
    A multi-layered and conserved cell cycle mechanism prevents capsulation, long known as a bacterial virulence determinant, in G1-phase and concurrently licenses bacteriophage-mediated genetic exchange prior to entry into S-phase.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    A structural mechanism for bacterial autotransporter glycosylation by a dodecameric heptosyltransferase family

    Qing Yao et al.
    Protein heptosyltransferases modify a group of bacterial autotransporters for virulence function and employ a novel structural mechanism for the processive hyperglycosylation of the autotransporter.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Vaccine Design: Chimeras could help in the fight against leptospirosis

    Jademilson C Santos, Ana Lucia TO Nascimento
    Understanding the structure of an antigen can guide the design of improved antigen-based vaccines.
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