Browse our Research Articles

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    1. Evolutionary Biology
    2. Genetics and Genomics

    Innovation of heterochromatin functions drives rapid evolution of essential ZAD-ZNF genes in Drosophila

    Bhavatharini Kasinathan et al.
    Heterochromatic sequences evolve rapidly, as do ZAD-ZNF genes-encoding proteins involved in heterochromatin functions, explaining why evolutionarily dynamic ZAD-ZNF genes are more likely to be essential in Drosophila.
    1. Ecology

    Group size and composition influence collective movement in a highly social terrestrial bird

    Danai Papageorgiou, Damien Roger Farine
    High-resolution GPS data revealed a quadratic relationship between group size and movement, with vulturine guineafowl groups of intermediate size exhibiting the largest home-range size and greater variation in site use.
    1. Cancer Biology

    Increased mTOR activity and metabolic efficiency in mouse and human cells containing the African-centric tumor-predisposing p53 variant Pro47Ser

    Keerthana Gnanapradeepan et al.
    Enhanced metabolic efficiency associated with the tumor-predisposing African-centric p53 variant.
    1. Genetics and Genomics

    Cohesin residency determines chromatin loop patterns

    Lorenzo Costantino et al.
    High-resolution mapping of cohesin-dependent chromatin loops in the genome of budding yeast reveals evolutionarily conserved features for loop formation and cohesin residency as a determinant of loop positioning.
    1. Neuroscience

    Chronic postnatal chemogenetic activation of forebrain excitatory neurons evokes persistent changes in mood behavior

    Sthitapranjya Pati et al.
    Enhanced Gq-signaling-mediated activation of forebrain excitatory neurons in postnatal life programs enhanced anxiety-, despair- and schizophrenia-like behavior, recapitulating key aspects of the behavioral consequences of early life adversity.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Evolution of multicellularity by collective integration of spatial information

    Enrico Sandro Colizzi et al.
    Selection for undifferentiated multicellularity emerges in an evolutionary cell-based model because a collective of cells performs chemotaxis better than single cells in a noisy environment.
    1. Microbiology and Infectious Disease

    A single mutation in Crimean-Congo hemorrhagic fever virus discovered in ticks impairs infectivity in human cells

    Brian L Hua et al.
    Tick-derived sequence variation in the fusion glycoprotein of Crimean-Congo hemorrhagic fever virus (CCHFV) drastically impairs infection of mammalian cells, suggesting that certain CCHFV strains undergo purifying selection in mammalian hosts.