TY - JOUR TI - Cell types and neuronal circuitry underlying female aggression in Drosophila AU - Schretter, Catherine E AU - Aso, Yoshi AU - Robie, Alice A AU - Dreher, Marisa AU - Dolan, Michael-John AU - Chen, Nan AU - Ito, Masayoshi AU - Yang, Tansy AU - Parekh, Ruchi AU - Branson, Kristin M AU - Rubin, Gerald M A2 - Ramaswami, Mani VL - 9 PY - 2020 DA - 2020/11/03 SP - e58942 C1 - eLife 2020;9:e58942 DO - 10.7554/eLife.58942 UR - https://doi.org/10.7554/eLife.58942 AB - Aggressive social interactions are used to compete for limited resources and are regulated by complex sensory cues and the organism's internal state. While both sexes exhibit aggression, its neuronal underpinnings are understudied in females. Here, we identify a population of sexually dimorphic aIPg neurons in the adult Drosophila melanogaster central brain whose optogenetic activation increased, and genetic inactivation reduced, female aggression. Analysis of GAL4 lines identified in an unbiased screen for increased female chasing behavior revealed the involvement of another sexually dimorphic neuron, pC1d, and implicated aIPg and pC1d neurons as core nodes regulating female aggression. Connectomic analysis demonstrated that aIPg neurons and pC1d are interconnected and suggest that aIPg neurons may exert part of their effect by gating the flow of visual information to descending neurons. Our work reveals important regulatory components of the neuronal circuitry that underlies female aggressive social interactions and provides tools for their manipulation. JF - eLife SN - 2050-084X PB - eLife Sciences Publications, Ltd ER - 管家婆期期准免费资料精选