@article {10.7554/eLife.58942, article_type = {journal}, title = {Cell types and neuronal circuitry underlying female aggression in \textit{Drosophila}}, author = {Schretter, Catherine E and Aso, Yoshi and Robie, Alice A and Dreher, Marisa and Dolan, Michael-John and Chen, Nan and Ito, Masayoshi and Yang, Tansy and Parekh, Ruchi and Branson, Kristin M and Rubin, Gerald M}, editor = {Ramaswami, Mani}, volume = 9, year = 2020, month = {nov}, pub_date = {2020-11-03}, pages = {e58942}, citation = {eLife 2020;9:e58942}, doi = {10.7554/eLife.58942}, url = {https://doi.org/10.7554/eLife.58942}, abstract = {Aggressive social interactions are used to compete for limited resources and are regulated by complex sensory cues and the organism's internal state. While both sexes exhibit aggression, its neuronal underpinnings are understudied in females. Here, we identify a population of sexually dimorphic aIPg neurons in the adult \textit{Drosophila melanogaster }central brain whose optogenetic activation increased, and genetic inactivation reduced, female aggression. Analysis of GAL4 lines identified in an unbiased screen for increased female chasing behavior revealed the involvement of another sexually dimorphic neuron, pC1d, and implicated aIPg and pC1d neurons as core nodes regulating female aggression. Connectomic analysis demonstrated that aIPg neurons and pC1d are interconnected and suggest that aIPg neurons may exert part of their effect by gating the flow of visual information to descending neurons. Our work reveals important regulatory components of the neuronal circuitry that underlies female aggressive social interactions and provides tools for their manipulation.}, journal = {eLife}, issn = {2050-084X}, publisher = {eLife Sciences Publications, Ltd}, } 管家婆期期准免费资料精选