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Structural Biology and Molecular Biophysics
DeepFRET, a software for rapid and automated single-molecule FRET data classification using deep learning
Johannes Thomsen et al.
An open-source user-friendly toolbox implementing machine learning for single-molecule FRET analysis enabling experts and non-experts to reproducibly provide dynamic structural biology insights.
Asymmetric neurogenic commitment of retinal progenitors involves Notch through the endocytic pathway
Elisa Nerli et al.
Cell types and neuronal circuitry underlying female aggression in
Catherine E Schretter et al.
Direct glia-to-neuron transdifferentiation gives rise to a pair of male-specific neurons that ensure nimble male mating
Laura Molina-García et al.
A novel developmental mechanism generates a previously undescribed pair of sex-specific proprioceptive neurons required for male-specific behaviour.
Physics of Living Systems
navigate complex plumes using stochastic decisions biased by the timing of odor encounters
Mahmut Demir et al.
Visualized odor encounters show that
navigate spatiotemporally complex odor plumes using random walks biased by the timing of brief and unpredictable odor encounters.
Single nuclei RNA-seq of mouse placental labyrinth development
Bryan Marsh, Robert Blelloch
Stem Cells and Regenerative Medicine
A fully automated high-throughput workflow for 3D-based chemical screening in human midbrain organoids
Henrik Renner et al.
Automated liquid handling, whole mount staining, and clearing allow unbiased 3D quantitation of cell markers in human neural organoids with diameters of up to 1 mm at the single-cell level.
Entorhinal-retrosplenial circuits for allocentric-egocentric transformation of boundary coding
Joeri BG van Wijngaarden et al.
An extended border coding circuit across the entorhinal and retrosplenial cortex incorporates self-referenced and viewpoint-invariant boundary information to guide navigation behavior.
Atg43 tethers isolation membranes to mitochondria to promote starvation-induced mitophagy in fission yeast
Tomoyuki Fukuda et al.
Atg43 serves as a selective autophagy receptor by tethering isolation membranes to mitochondria to promote mitophagy and plays a mitophagy-independent role that facilitates normal cell growth in fission yeast.
Protein phase separation and its role in tumorigenesis
Shan Jiang et al.
The current understanding of phase separation is summarized and its emerging roles in cancer are discussed in detail.
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